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Mefenamic acid

CAS No. 61-68-7

Mefenamic acid( C.I. 473 | NSC 94437 )

Catalog No. M15330 CAS No. 61-68-7

Mefenamic acid is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of mefenamic acid is as a Cyclooxygenase Inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Mefenamic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Mefenamic acid is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of mefenamic acid is as a Cyclooxygenase Inhibitor.
  • Description
    Mefenamic acid is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of mefenamic acid is as a Cyclooxygenase Inhibitor. The chemical classification of mefenamic acid is Nonsteroidal Anti-inflammatory Compounds.(In Vitro):Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively. Mefenamic acid (0-100 μM) has cytotoxic effects on KB, Saos-2, and 1321N cells, however, U-87MG cells are resistant to Mefenamic acid.
  • In Vitro
    Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively. Mefenamic acid (0-100 μM) has cytotoxic effects on KB, Saos-2, and 1321N cells, however, U-87MG cells are resistant to Mefenamic acid.
  • In Vivo
    ——
  • Synonyms
    C.I. 473 | NSC 94437
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    COX-1| COX-2
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    61-68-7
  • Formula Weight
    241.29
  • Molecular Formula
    C15H15NO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 48 mg/mL (198.93 mM)
  • SMILES
    c1(c(cccc1)C(=O)O)Nc1c(c(ccc1)C)C
  • Chemical Name
    2-(2,3-dimethylanilino)benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bhat AS, et al. Eur J Pharmacol. 2007 Feb 5; 556(1-3):190-9.
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